What do you want from me?

你到底要我怎样

你想从我这得到什么

Adam Lambert 演唱的歌曲《Whataya Want from Me》中就有这句话。

对比：What do you want with me? 和 What do you want from me?

"What do you want with me?"

means roughly "Why are you seeking me out?"

你为什么找我

"What do you want from me?"

means roughly "What do you expect (to get) from me?"

你想从我这里得到什么

If a girlfriend said, "I always thought I would end up with someone who was more successful", the two questions would convey very different moods.

如果女朋友说，“我一直认为我会和一个更成功的人在一起”，这两句话会传达出截然不同的情绪。

"What do you want with me?" = "Why are you in a relationship with me, then?"

那你为什么和我在一起

"What do you want from me?" = "What do you expect me to do (to fulfill these wishes of yours)?"

你希望我做什么(来满足你的这些愿望)?